Aliskiren, enalapril, or aliskiren and enalapril in heart. If you have diabetes, do not use aliskiren together with certain heart or blood pressure medicines, such as. We compared the ace inhibitor enalapril with the renin inhibitor aliskiren to test superiority or at least noninferiority and with the combination of the two treatments to test superiority in. Aliskiren brand names tekturna and rasilez is the first in a class of drugs called direct renin inhibitors. Compare prices, print coupons and get savings tips for aliskiren and hydrochlorothiazide tekturna hct and other hypertension drugs at cvs. The warning also applies to patients who have renal impairment.
Texas prior authorization program clinical criteria 150mg aliskirencontaining agents except valturna. May 23, 2016 a subgroup analysis in heart failure patients with diabetes from the atmosphere trial has failed to show benefit and signals the end of the road for aliskiren in heart failure. On april 19, the us food and drug administration issued a warning to diabetes patients not to combine the blood pressure medication aliskiren tekturna with ace inhibitors or angiotensin receptor blockers. Drug interactions with aliskiren oral and lisinoprilhydrochlorothiazide oral. Aliskirencontaining bp drugs in combination with ace inhibitors and arbs are now contraindicated for patients with diabetes based on the aborted altitude study, the. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr. Pricing, sizing, legal catgories and other medicinal forms information for aliskiren. Aliskiren rasilez, a direct renin inhibitor, is currently indicated for the treatment of essential hypertension, as monotherapy or in combination, especially. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Compare prices, print coupons and get savings tips for aliskiren and hydrochlorothiazide tekturna hct and other hypertension drugs at cvs, walgreens, and other pharmacies. You should not take aliskiren if you are allergic to it. Angiotensinconverting enzyme inhibitors and angiotensin ii type 1 receptor antagonists angiotensin receptor blockers have been shown to be effective drugs in the management of hypertension and to have beneficial effects along the cardiovascular continuum. While used for high blood pressure, other better studied medications are typically recommended due to concerns of higher side effects and less evidence of benefit.
Aliskiren medicinal forms bnf content published by nice. Il ruolo di aliskiren nella terapia antipertensiva non e ben definito. Learn about drug interactions between aliskiren oral and lisinoprilhydrochlorothiazide oral and use the rxlist drug interaction checker to check drug combinations. Tekturna aliskiren dosing, indications, interactions. Aliskiren in the management of hypertension springerlink.
Aliskiren is the first in a new class of orally active, nonpeptide, low molecular weight direct renin inhibitor dri available for clinical. Aliskiren tekturna for hypertension the medical letter. This supplemental new drug application provides for labeling revised as follows additions are marked as. Mechanism of action renin catalyzes the cleavage of angiotensinogen to form angiotensin i, the first and ratelimiting step of the renin. Find patient medical information for aliskiren oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The fda said that patients with diabetes who mix the drugs risk kidney damage, hypotension extremely low blood pressure.
When used as a singleagent treatment, aliskiren rasilez was shown to provide similar efficacy in blood pressure reduction as ace inhibitors, angiotensin ii receptor blockers, betablockers and thiazide diuretics. Hypersensitivity reactions eg, anaphylactic reactions and angioedema of the face, extremities, lips, tongue, glottis andor larynx have been reported in patients treated with aliskiren and has necessitated hospitalization and intubation. Tekturna aliskiren tablets side effects, images, uses. It is indicated for oral use either as monotherapy or in combination with other antihypertensive agents. Tekturna novartis, the first direct renin inhibitor, has been approved by the fda for treatment of hypertension. Nov 09, 2018 aliskiren is an antihypertensive blood pressure lowering medicine. Aliskiren tekturna for hypertension the medical letter, inc. Aliskiren combined with losartan in type 2 diabetes and. Aliskiren containing bp drugs in combination with ace inhibitors and arbs are now contraindicated for patients with diabetes based on the aborted altitude study, the fda announced.
A subgroup analysis in heart failure patients with diabetes from the atmosphere trial has failed to show benefit and signals the end of the road for aliskiren in heart failure. Coadministration with arbs or ace inhibitors in patients with diabetes mellitus. Aliskiren tekturna, rasilez contraindicated with ace. Pdf inhibicion del sistema reninaangiotensinaaldosterona en. Aliskiren binds only moderately to plasma proteins mean proteinbounding level of 49. It works by decreasing substances in the body that narrow blood vessels and raise blood pressure. Combination therapy with two drugs affecting the reninangiotensin system ace inhibitors, angiotensinii receptor antagonists, and aliskiren is not recommended due to an increased risk of hyperkalaemia, hypotension, and renal impairment, compared to use of a single drug. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Aliskiren may also be used for purposes not listed in this medication guide. Nov 28, 2017 what should i discuss with my healthcare provider before taking aliskiren tekturna. Fda warns diabetes patients about combining aliskiren april 30, 2012 nadia alsamarrie 0 comments. Dec 11, 2014 the altitude study aliskiren trial in type 2 diabetes using cardiovascular and renal disease endpoints was a 4year, multicentre, randomised, placebocontrolled trial that looked at type ii. Aliskiren tekturna aliskiren is a small molecule antihypertensive that was discovered as part of a study to develop inhibitors of the enzyme renin, a key regulator of blood pressure control a viable process synthesis was developed by speedelnovartis, which won approval for the drug from the fda in 2007 first in its class difficult. Aliskiren should be taken either always with food or always without food.
1521 1312 746 1617 1588 1337 1611 235 902 128 1051 648 282 1519 815 1218 216 205 1541 1154 594 436 307 534 281 538 1425 781 487 145 374 1113 232 839 1461 324 639 251 6 807